Malignant Deamination Drives Cancer Stem Cell Generation
Catriona Jamieson, MD, PhD UC San Diego Moores Cancer Center
Sanford Stem Cell CLinical Center
CIRM Alpha Stem Cell Clinic
Catriona Jamieson, MD, PhD Director, Sanford Stem Cell Clinical Center
Director, UC San Diego Health CIRM Alpha Stem Cell Clinic
Deputy Director, UC San Diego Moores Cancer Center
Professor of Medicine and Chief, Division of Regenerative Medicine
Koman Family Presidential Endowed Chair in Cancer Research
Catriona Jamieson, M.D., Ph.D., is Professor of Medicine in the Division of Hematology-Oncology, Deputy Director at UC San Diego Moores Cancer Center, Koman Family Presidential Endowed Chair in Cancer Research, Chief of the Division of Regenerative Medicine, Director of the Sanford Stem Cell Clinical Center, Co-Leader of the Hematologic Malignancies Program, and Director of Stem Cell Research at UC San Diego Moores Cancer Center.
Dr. Jamieson specializes in myeloproliferative disorders (MPDs) and leukemia. Myeloproliferative neoplasms are a family of uncommon but not rare degenerative disorders in which the body overproduces blood cells. Myeloproliferative neoplasms can cause many forms of blood clotting including heart attack, stroke, deep venous thrombosis, and pulmonary emboli and can develop into acute myelogenous leukemia. Although some effective treatments are available, they are laden with serious side effects. In addition, individuals can become resistant to the treatments. Dr. Jamieson studies the mutant stem cells and progenitor cells in myeloproliferative neoplasms. These cells can give rise to cancer stem cells. Cancer stem cells may lie low to evade chemotherapy and then activate again later, causing disease progression and resistance to treatment. Her goal is to find more selective, less toxic therapies.
Dr. Jamieson received her medical and doctorate degrees from the University of British Columbia. She completed her residency and clinical fellowships in bone marrow transplantation and hematology, as well as her postdoctoral research fellowship in the laboratory of Professor Irving Weissman at Stanford.
